Qualitative modeling of the immune response: from mechanisms to populations

Aurelien Naldi (ENS)
Thursday, January 9, 2020 - 10:30 to 12:00
Room Aurigny
Talk abstract: 

Qualitative dynamical models, based on generalized Boolean functions, have been used over the last decades to study complex biological systems. As a reasoning tool for researchers in biology, they facilitate the identification of missing or inconsistent knowledge, and can ultimately guide experimental design. We are interested in particular in the regulation of the immune response. In this context, we assembled and analyzed a comprehensive model of the differentiation and plasticity of regulatory T cells, which are heavily define the nature and amplitude of this response. However, these cells are not isolated actors, they interact with each other and with several other types of cells through chemical signals. We are currently extending existing modelling tools to account for large-scale populations of mechanical models. In the long term, we aim to reduce the gap between mechanistic models at the single cell scale and phenomenological ones at the population scale.